Which of the following refers to the combination of various symptoms associated with substance use?

The term that refers to the combination of various symptoms associated with substance use is addiction. Addiction is a complex condition characterized by compulsive drug seeking, continued use despite harmful consequences, and long-lasting changes in the brain. This includes a range of symptoms across physical, psychological, and behavioral dimensions—such as persistent cravings for the substance, tolerance to its effects, and withdrawal symptoms upon cessation of use.

Other terms—such as craving, tolerance, and physical dependence—represent more specific aspects of substance use and addiction. Craving pertains specifically to the intense desire to use the substance, while tolerance involves a person's diminished response to a substance following repeated use, necessitating larger amounts to achieve the same effect. Physical dependence describes the physiological adaptations that occur with prolonged substance use, leading to withdrawal symptoms when use is reduced or stopped. Collectively, these symptoms contribute to the broader condition of addiction, but they do not encompass the full array of behavioral and cognitive symptoms that define addiction itself.