Which individual is at a higher risk for peripheral neuropathy?

The individual characterized by having diabetes and high blood sugars is at a higher risk for peripheral neuropathy due to the effects of prolonged elevated glucose levels on the nervous system. Diabetes can lead to damage in the nerves, particularly when blood sugar levels are poorly managed over time. This damage is often caused by a combination of factors including inflammation, oxidative stress, and metabolic imbalances that affect nerve fibers.

Peripheral neuropathy commonly occurs in individuals with uncontrolled diabetes because persistent high blood sugar can lead to excess glucose binding to proteins, which in turn disrupts normal nerve function. Symptoms of peripheral neuropathy can include pain, numbness, tingling, and weakness in the extremities.

In contrast, individuals without conditions such as diabetes, particularly those who are younger with normal health parameters, present a lower risk for developing this type of neuropathy, as their nervous systems are less likely to be exposed to the damaging effects associated with high blood sugar.