Wernicke-Korsakoff syndrome is caused when alcohol reduces absorption of which of the following?

Wernicke-Korsakoff syndrome is primarily associated with a deficiency in thiamine (also known as vitamin B1), which is crucial for energy metabolism in the brain. Chronic alcohol consumption interferes with the absorption of thiamine in the gastrointestinal tract and also affects its conversion to its active form, thiamine pyrophosphate. This deficiency leads to neurological symptoms and cognitive impairments characteristic of Wernicke-Korsakoff syndrome, including confusion, memory issues, and motor coordination problems. The connection between alcohol and thiamine absorption is well-established, making thiamine the key nutrient related to this syndrome.