In addition to prostaglandin, which substance is also known to contribute to pain sensation?

Histamine plays a significant role in the body's physiological response to injury or allergens, contributing to pain sensation primarily through its involvement in inflammatory processes. When tissues are damaged or an allergen is present, histamine is released from mast cells and basophils. Its release leads to vasodilation and increased permeability of blood vessels, which allows fluid and immune cells to reach the affected area. This process not only helps in healing but also sensitizes nerve endings, which can amplify the pain sensation in the affected area.

Histamine's action in the central nervous system further influences pain perception, making it an important mediator in both acute and chronic pain states. By interacting with specific receptors, histamine can enhance the perception of pain stimuli, thereby contributing to the overall experience of pain alongside other substances like prostaglandins. This interaction is crucial in the body's pain signaling pathways, linking inflammation with increased pain sensitivity.